Web1. Introduction. Clinical guidelines for obesity typically recommend considering pharmacotherapy, such as treatment with a GLP-1RA, for achievement of weight loss and … WebOct 3, 2024 · In this respect, GLP-1RAs differ from DPP-4is, which increase circulating GLP-1 levels without affecting satiety or gastric emptying and, therefore, do not markedly affect body weight [Citation 47]. GLP-1RAs may also affect body weight by increasing thermogenesis within brown adipose tissue, a downstream effect of central GLP-1 …
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